Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.79 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.72 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058830 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL3211535 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL767101 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL1981026 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL767546 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL630093 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL9702784 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL7902534 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL1636300 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL767032 | 1.00 | TYMS (0.79) | TYMSLPAR3LPAR2LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513760-A2 | Use of biphosphonate squalene synthetase inhibitors in pharmaceutical compositions useful in lowering cholesterol | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | claimed |
| EP-0513760-A2 | Use of biphosphonate squalene synthetase inhibitors in pharmaceutical compositions useful in lowering cholesterol | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |