Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8584058 | 0.84 | KDM4E (0.50) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL19642751 | 0.83 | PNP (0.55) | POLA1PNPLMNATP53HTT | |
| SCHEMBL8896723 | 0.79 | CYP1A2 (0.51) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL6898732 | 0.78 | POLA1 (0.49) | POLA1PNPLMNATP53HTT | |
| SCHEMBL264545 | 0.76 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL12714741 | 0.76 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL264546 | 0.76 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL25507075 | 0.76 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL20346237 | 0.76 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 | |
| SCHEMBL10068104 | 0.76 | KDM4E (0.72) | POLA1KDM4EPNPLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992013869-A1 | METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM | GILEAD SCIENCES, INC. (US) | 1992-08-20 | — | — | WO | disclosed |