Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650589 | 0.90 | CA1 (0.51) | CYP19A1CA1CA2CA9CA12 | |
| SCHEMBL30155019 | 0.90 | CA1 (0.51) | CYP19A1CA1CA2CA9CA12 | |
| Sulfuric Acid SCHEMBL1491064 | 0.88 | CA1 (0.48) | CTNNB1WNT3ACYP19A1CA1CA2 | |
| SCHEMBL6263512 | 0.79 | HDAC1 (0.56) | CTNNB1WNT3AHDAC1HDAC8PPARG | |
| SCHEMBL28325361 | 0.77 | HDAC1 (0.60) | CTNNB1WNT3AHDAC1HDAC8ENPP2 | |
| SCHEMBL29518264 | 0.76 | MAPT (0.56) | CTNNB1WNT3AHDAC1HDAC8MAPT | |
| SCHEMBL3400912 | 0.76 | MAPT (0.56) | CTNNB1WNT3AHDAC1HDAC8MAPT | |
| SCHEMBL27984209 | 0.75 | HDAC1 (0.63) | CTNNB1WNT3AHDAC1HDAC8MAPT | |
| SCHEMBL1650349 | 0.75 | CA12 (0.49) | CYP19A1CA1CA2CA9CA12 | |
| SCHEMBL8990514 | 0.74 | EPHX2 (0.53) | CYP19A1CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992011003-A1 | PHARMACEUTICAL COMPOSITIONS | LABORATOIRES GLAXO S.A. (FR) | 1992-07-09 | — | — | WO | claimed |