Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of (S)-P-Hydroxyamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.95 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamphetamine SCHEMBL28160718 | 1.00 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL221647 | 1.00 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL221649 | 1.00 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| (S)-P-Hydroxyamphetamine SCHEMBL256809 | 0.98 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL125442 | 0.98 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL125440 | 0.98 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL221291 | 0.95 | TAAR1 (0.95) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL219710 | 0.95 | TAAR1 (0.95) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL219712 | 0.95 | TAAR1 (0.95) | TAAR1SLC6A2SLC6A3SLC6A4MAOA | |
| Hydroxyamphetamine SCHEMBL11539011 | 0.95 | TAAR1 (0.95) | TAAR1SLC6A2SLC6A3SLC6A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0502498-A1 | Phenoxyalkanoic acid derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1992-09-09 | — | — | EP | disclosed |