Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | NAAA | Q02083 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146225 | 0.87 | CYP1A2 (0.43) | CYP1A2ALDH1A1LMNATP53TSHR | |
| SCHEMBL20488928 | 0.83 | CYP1A2 (0.75) | CYP1A2 | |
| SCHEMBL15517594 | 0.83 | CYP1A2 (0.51) | CYP1A2NAAAALDH1A1LMNATP53 | |
| SCHEMBL29874518 | 0.81 | CYP1A2 (0.73) | CYP1A2 | |
| SCHEMBL363462 | 0.81 | CYP1A2 (0.73) | CYP1A2 | |
| SCHEMBL8530634 | 0.81 | CYP1A2 (0.67) | CYP1A2LMNATP53 | |
| SCHEMBL363328 | 0.80 | CYP1A2 (0.42) | CYP1A2ALDH1A1LMNATP53TSHR | |
| SCHEMBL9709549 | 0.77 | CHRM2 (0.38) | CYP1A2NAAACHRM2CHRM4CHRM5 | |
| SCHEMBL29143658 | 0.77 | CYP1A2 (0.56) | CYP1A2ALDH1A1LMNATP53TSHR | |
| SCHEMBL11112219 | 0.76 | CHRM2 (0.40) | CYP1A2NAAACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0493324-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |