Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.75 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.75 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.75 |
| ▸ | SHBG | P04278 | 4/20 | 0.75 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | PGR | P06401 | 3/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 6/20 | 0.73 |
| ▸ | BLM | P54132 | 3/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711310 | 1.00 | HIF1A (0.75) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| SCHEMBL141582 | 0.89 | HIF1A (0.74) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| SCHEMBL30297286 | 0.89 | HIF1A (0.74) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| Hydrocortisone SCHEMBL19465688 | 0.86 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| Hydrocortisone SCHEMBL143923 | 0.86 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| Hydrocortisone SCHEMBL24900238 | 0.86 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| Hydrocortisone SCHEMBL6932400 | 0.86 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| Hydrocortisone SCHEMBL12737556 | 0.86 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| Hydrocortisone SCHEMBL5699764 | 0.86 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 | |
| Hydrocortisone SCHEMBL10261067 | 0.86 | HIF1A (1.00) | HIF1AHSD17B10NR3C1SERPINA6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5096892-A | Arylsulfatase inhibition and potentiation of angiostatic steroids and heparin | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| US-5021404-A | Angiostatic collagen modulators | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1991-06-04 | — | — | US | disclosed |
| US-4994443-A | Administering heparin or a derivative thereof and a steroid | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |