Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857365 | 0.93 | NR1H4 (0.52) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9713717 | 0.92 | NR1H4 (0.54) | NR1H4CREBBPMAPTLMNAPOLB | |
| SCHEMBL9713032 | 0.92 | PLK1 (0.53) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9857546 | 0.91 | NR1H4 (0.52) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9856932 | 0.90 | MAPT (0.52) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9857411 | 0.90 | NR1H4 (0.51) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9857326 | 0.90 | NR1H4 (0.51) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9713720 | 0.90 | NR1H4 (0.51) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9712885 | 0.90 | NR1H4 (0.51) | NR1H4MAPTLMNAPOLBHDAC1 | |
| SCHEMBL9857341 | 0.90 | NR1H4 (0.51) | NR1H4MAPTLMNAPOLBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140046-A | Slow reacting substance of anaphylaxis antagonists | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |
| US-5116853-A | SRS-Antagonist, Antiallergens | MASE TOSHIYASU (JP) | 1992-05-26 | — | — | US | disclosed |
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0218728-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986005779-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-09 | — | — | WO | disclosed |