Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 2/20 | 0.37 |
| ▸ | CDC25B | P30305 | 2/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 2/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | GAPDH | P04406 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713893 | 0.94 | IDO1 (0.42) | IDO1CDC25ACDC25BTDP2NSD2 | |
| SCHEMBL9643315 | 0.85 | NOTUM (0.35) | IDO1CDC25ACDC25BNSD2HKDC1 | |
| SCHEMBL9642418 | 0.78 | NOTUM (0.39) | IDO1CDC25ACDC25BNSD2HKDC1 | |
| SCHEMBL9713898 | 0.77 | CDC25A (0.36) | IDO1CDC25ACDC25BTDP2NSD2 | |
| SCHEMBL9713541 | 0.71 | NSD2 (0.59) | IDO1CDC25ACDC25BTDP2NSD2 | |
| SCHEMBL9714090 | 0.71 | IDO1 (0.44) | IDO1CDC25ACDC25BTDP2NSD2 | |
| SCHEMBL9713823 | 0.69 | IDO1 (0.48) | IDO1CDC25ACDC25BTDP2NSD2 | |
| SCHEMBL9713755 | 0.69 | IDO1 (0.51) | IDO1CDC25ACDC25BTDP2NSD2 | |
| SCHEMBL9713498 | 0.68 | CDC25A (0.47) | IDO1CDC25ACDC25BTDP2NSD2 | |
| SCHEMBL9714052 | 0.67 | CDC25A (0.40) | IDO1CDC25ACDC25BTDP2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |