Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.61 |
| ▸ | TDO2 | P48775 | 4/20 | 0.61 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714864 | 0.98 | IDO1 (0.64) | IDO1TDO2IDO2SLC6A2SLC6A4 | |
| SCHEMBL1505811 | 0.82 | SCN1A (0.50) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL10654015 | 0.81 | IDO1 (0.44) | IDO1TDO2IDO2SLC6A2SLC6A4 | |
| SCHEMBL10577158 | 0.81 | IDO1 (0.58) | IDO1TDO2IDO2SLC6A2SLC6A4 | |
| SCHEMBL7429799 | 0.74 | IDO1 (0.50) | IDO1TDO2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10571717 | 0.72 | CYP1A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9714844 | 0.72 | IDO1 (0.54) | IDO1TDO2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16759094 | 0.69 | IDO1 (0.55) | IDO1TDO2IDO2SLC6A2SLC6A4 | |
| SCHEMBL17802363 | 0.68 | SLC6A4 (0.54) | IDO1TDO2IDO2SLC6A2SLC6A4 | |
| SCHEMBL2336595 | 0.68 | IDO1 (0.51) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116988-A | Antiepileptic | WARNER-LAMBERT CO. (US) | 1992-05-26 | — | — | US | disclosed |
| US-5053521-A | 3-amino butyric acid uptake inhibitors, antiepileptic agents | WARNER-LAMBERT COMPANY (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0221572-B1 | N-SUBSTITUTED 3-PIPERIDINE-OR 3-PYRIDINE-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-09-25 | — | — | EP | disclosed |
| US-4910312-A | Containing 1-(2-(bis((4-trifluoromethylphenyl)methoxy)-ethyl)-substitution | WARNER-LAMBERT COMPANY (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0346927-A2 | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridine-carboxylic acids and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4772615-A | ANTICONVULSANT FOR TREATING EPILEPSY | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0221572-A2 | N-substituted 3-piperidine-or 3-pyridine-carboxylic acids and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |