SCHEMBL9716003

SCHEMBL9716003

C#CCn1c(=O)oc2ccc(Cl)cc21

nearest known ligand 0.64

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 11/20 0.64
KMO O15229 1/20 0.58
NOS3 P29474 5/20 0.57
NOS1 P29475 5/20 0.57
NOS2 P35228 5/20 0.57
TMEM97 Q5BJF2 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22802595 0.88 TDP1 (0.49) IDO1KMONOS3NOS1NOS2
SCHEMBL9715941 0.82 IDO1 (0.61) IDO1KMONOS3NOS1NOS2
SCHEMBL9715935 0.82 IDO1 (0.61) IDO1KMONOS3NOS1NOS2
SCHEMBL10504839 0.82 IDO1 (0.42) IDO1KMONOS3NOS1NOS2
SCHEMBL23964619 0.80 IDO1 (0.69) IDO1KMONOS3NOS1NOS2
SCHEMBL6425871 0.80 IDO1 (0.69) IDO1KMONOS3NOS1NOS2
SCHEMBL10507200 0.78 IDO1 (0.63) IDO1KMO
SCHEMBL3027838 0.78 MAPK1 (0.66) IDO1
SCHEMBL14198758 0.77 IDO1 (0.66) IDO1KMONOS3NOS1NOS2
SCHEMBL19398562 0.76 IDO1 (0.67) IDO1KMONOS3NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5102898-A Halosubstituted alkyne group; fungicides ROHM AND HAAS COMPANY (US) 1992-04-07 US disclosed