Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 15/20 | 0.76 |
| ▸ | KDR | P35968 | 14/20 | 0.76 |
| ▸ | AURKA | O14965 | 12/20 | 0.58 |
| ▸ | LCK | P06239 | 12/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.56 |
| ▸ | ERN1 | O75460 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974129 | 0.95 | TEK (0.78) | TEKKDRAURKALCKAURKB | |
| SCHEMBL971610 | 0.74 | TEK (1.00) | TEKKDRAURKALCKAURKB | |
| SCHEMBL973707 | 0.74 | TEK (0.85) | TEKKDRAURKALCKAURKB | |
| SCHEMBL974586 | 0.73 | TEK (1.00) | TEKKDRAURKALCKAURKB | |
| SCHEMBL973870 | 0.73 | TEK (1.00) | TEKKDRAURKALCKAURKB | |
| SCHEMBL972856 | 0.71 | TEK (0.71) | TEKKDRAURKALCKAURKB | |
| SCHEMBL5263752 | 0.71 | AURKB (0.79) | TEKKDRAURKALCKAURKB | |
| SCHEMBL974793 | 0.70 | TEK (0.70) | TEKKDRAURKALCKAURKB | |
| SCHEMBL973163 | 0.69 | TEK (1.00) | TEKKDRAURKALCKAURKB | |
| SCHEMBL24439393 | 0.69 | TEK (0.62) | TEKKDRAURKALCKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | disclosed |