Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 6/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | KLK7 | P49862 | 4/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.48 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29687334 | 0.96 | SYK (0.54) | SYKMAPTCTSSPPARAKLK7 | |
| SCHEMBL13723801 | 0.96 | SYK (0.63) | SYKMAPTCTSSPPARACTSK | |
| SCHEMBL21906231 | 0.89 | SYK (0.51) | SYKMAPTCTSSPPARAKLK7 | |
| SCHEMBL21906212 | 0.89 | SYK (0.51) | SYKMAPTCTSSPPARAKLK7 | |
| SCHEMBL20669513 | 0.88 | PPARA (0.64) | SYKMAPTCTSSPPARAKLK7 | |
| SCHEMBL17773023 | 0.87 | MAPT (0.66) | MAPTKLK7KLK5ITGB3ITGA2B | |
| SCHEMBL18340847 | 0.87 | SYK (0.64) | SYKMAPTCTSSPPARAKLK7 | |
| SCHEMBL6231600 | 0.87 | SYK (0.64) | SYKMAPTCTSSPPARAKLK7 | |
| SCHEMBL14842312 | 0.87 | SYK (0.64) | SYKMAPTCTSSPPARAKLK7 | |
| SCHEMBL20297671 | 0.87 | SYK (0.64) | SYKMAPTCTSSPPARAKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0374952-A2 | 7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E.R. SQUIBB & SONS, INC. (US) | 1990-06-27 | — | — | EP | disclosed |