Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21635473 | 0.96 | EPHX1 (0.68) | EPHX1SMN1; SMN2EPHX2HDAC3HDAC1 | |
| SCHEMBL12894206 | 0.83 | EPHX1 (0.65) | EPHX1EPHX2HDAC1HDAC6GAA | |
| SCHEMBL24435431 | 0.83 | EPHX1 (0.65) | EPHX1EPHX2HDAC1HDAC6GAA | |
| SCHEMBL8693601 | 0.83 | EPHX1 (0.64) | EPHX1SMN1; SMN2EPHX2GAATDP1 | |
| SCHEMBL26043679 | 0.81 | EPHX1 (0.62) | EPHX1SMN1; SMN2EPHX2HDAC1HDAC6 | |
| SCHEMBL12942650 | 0.81 | EPHX1 (0.67) | EPHX1SMN1; SMN2EPHX2HDAC1HDAC6 | |
| SCHEMBL14506128 | 0.80 | EPHX1 (1.00) | EPHX1EPHX2GAA | |
| SCHEMBL20010904 | 0.79 | EPHX1 (0.63) | EPHX1SMN1; SMN2EPHX2HDAC1HDAC6 | |
| SCHEMBL25495471 | 0.79 | EPHX1 (0.63) | EPHX1SMN1; SMN2EPHX2HDAC1HDAC6 | |
| SCHEMBL15502085 | 0.79 | TDP1 (0.48) | EPHX1HDAC8GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |