Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TOP2A | P11388 | 8/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866482 | 0.85 | TOP2A (0.67) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL9720535 | 0.84 | TOP2A (0.55) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL8194488 | 0.83 | TOP2A (0.67) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10591008 | 0.82 | TOP2A (0.59) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL9720505 | 0.81 | TOP2A (0.69) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL27445710 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10330778 | 0.79 | KDM4E (0.64) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL27444673 | 0.79 | TOP2A (0.56) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10590986 | 0.79 | TOP2A (0.56) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL27445403 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1TOP2ATOP2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417669-A2 | Pyridinyl-quinolone compounds, their preparation and use | STERLING WINTHROP INC. (US) | 1991-03-20 | — | — | EP | claimed |
| US-5169853-A | Antibacterial agents; administering to mammals for infection | STERLING DRUG INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5075319-A | Bactericides | STERLING DRUG INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0417669-A2 | Pyridinyl-quinolone compounds, their preparation and use | STERLING WINTHROP INC. (US) | 1991-03-20 | — | — | EP | disclosed |