Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9722706 | 1.00 | HSD17B10 (0.52) | HSD17B10KDM4EUSP2ESR1POLB | |
| SCHEMBL9722712 | 1.00 | HSD17B10 (0.52) | HSD17B10KDM4EUSP2ESR1POLB | |
| SCHEMBL3250724 | 0.79 | HSD17B10 (0.58) | HSD17B10KDM4ETSHRGLAHTT | |
| SCHEMBL5671154 | 0.76 | HSD17B10 (0.61) | HSD17B10KDM4ETSHRGLAHTT | |
| SCHEMBL9629704 | 0.73 | BRD4 (0.55) | HSD17B10KDM4EPOLBTSHRTP53 | |
| SCHEMBL10732070 | 0.72 | HSD17B10 (0.61) | HSD17B10KDM4EUSP2ESR1POLB | |
| SCHEMBL5671626 | 0.72 | HSD17B10 (0.65) | HSD17B10KDM4ETSHRGLAHTT | |
| SCHEMBL9287395 | 0.72 | BRD4 (0.57) | HSD17B10KDM4ETSHRGLAHTT | |
| SCHEMBL8853215 | 0.71 | BRD4 (0.56) | HSD17B10KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL10733251 | 0.71 | HSD17B10 (0.62) | HSD17B10KDM4EUSP2ESR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128468-A | Process for preparing 2-aryl-3-hydroxy-cis-2,3-dihydro-1,5-benzothiazepin-4(5H)-ones and their derivatives | FIS--Fabbrica Italiana Sintetici S.p.A. (IT) | 1992-07-07 | — | — | US | claimed |
| US-5128468-A | Process for preparing 2-aryl-3-hydroxy-cis-2,3-dihydro-1,5-benzothiazepin-4(5H)-ones and their derivatives | FIS--Fabbrica Italiana Sintetici S.p.A. (IT) | 1992-07-07 | — | — | US | disclosed |
| US-5128468-A | Process for preparing 2-aryl-3-hydroxy-cis-2,3-dihydro-1,5-benzothiazepin-4(5H)-ones and their derivatives | FIS--Fabbrica Italiana Sintetici S.p.A. (IT) | 1992-07-07 | — | — | US | disclosed |