Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11816688 | 0.92 | KCNH2 (0.46) | KCNH2TDP1L3MBTL1KDM5AKDM4C | |
| SCHEMBL5150752 | 0.86 | KDM4E (0.41) | KCNH2L3MBTL1TLR8 | |
| Bicarbonate SCHEMBL11817435 | 0.86 | KDM5A (0.45) | KCNH2TDP1L3MBTL1KDM5AKDM4C | |
| Methane SCHEMBL9587841 | 0.85 | KDM4E (0.40) | KCNH2L3MBTL1TLR8 | |
| SCHEMBL11561943 | 0.79 | KCNH2 (0.55) | KCNH2TDP1L3MBTL1CYP19A1PDPK1 | |
| SCHEMBL899234 | 0.79 | KCNH2 (0.55) | KCNH2TDP1L3MBTL1PDPK1TLR8 | |
| Bicarbonate SCHEMBL11821458 | 0.79 | KDM4E (0.39) | L3MBTL1KDM5AKDM4CKDM5B | |
| SCHEMBL17053275 | 0.78 | KCNH2 (0.58) | KCNH2TDP1L3MBTL1CYP19A1ADRB3 | |
| SCHEMBL22298878 | 0.78 | KCNH2 (0.58) | KCNH2TDP1L3MBTL1CYP19A1ADRB3 | |
| SCHEMBL3248683 | 0.78 | KCNH2 (0.53) | KCNH2PDPK1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175293-A | Substituted 2-aminopyrimidine derivatives | CIBA-GEIGY CORPORATION (US) | 1992-12-29 | — | — | US | disclosed |