Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.42 |
| ▸ | TUBB | P07437 | 4/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724015 | 1.00 | PTAFR (0.50) | PTAFRACHEPTPN1MAPTCYP3A4 | |
| SCHEMBL9724021 | 1.00 | PTAFR (0.50) | PTAFRACHEPTPN1MAPTCYP3A4 | |
| SCHEMBL9719927 | 0.83 | PTAFR (0.50) | PTAFRACHEPTPN1MAPTCYP3A4 | |
| SCHEMBL9719931 | 0.83 | PTAFR (0.50) | PTAFRACHEPTPN1MAPTCYP3A4 | |
| SCHEMBL9719064 | 0.77 | PTAFR (0.55) | PTAFRACHEPTPN1MAPTMEN1 | |
| SCHEMBL9719047 | 0.77 | PTAFR (0.55) | PTAFRACHEPTPN1MAPTMEN1 | |
| SCHEMBL9719028 | 0.77 | PTAFR (0.55) | PTAFRACHEPTPN1MAPTMEN1 | |
| SCHEMBL29267402 | 0.71 | PTAFR (0.62) | PTAFRACHEPTPN1MAPTCYP3A4 | |
| SCHEMBL9719054 | 0.69 | PTAFR (0.55) | PTAFRACHEPTPN1MAPTCYP3A4 | |
| SCHEMBL9719044 | 0.69 | PTAFR (0.55) | PTAFRACHEPTPN1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |