Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.41 |
| ▸ | GNPAT | O15228 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9561353 | 0.96 | GSR (0.52) | FOLH1GSRDPP8DPP9DPP7 | |
| SCHEMBL9561349 | 0.96 | GSR (0.52) | FOLH1GSRDPP8DPP9DPP7 | |
| SCHEMBL31078326 | 0.93 | FOLH1 (0.49) | FOLH1GSRDPP8DPP9DPP7 | |
| SCHEMBL31078152 | 0.93 | FOLH1 (0.49) | FOLH1GSRDPP8DPP9DPP7 | |
| SCHEMBL31078832 | 0.93 | FOLH1 (0.49) | FOLH1GSRDPP8DPP9DPP7 | |
| Hydrochloric Acid SCHEMBL1419587 | 0.93 | GSR (0.58) | FOLH1GSRDPP8DPP9DPP7 | |
| Hydrochloric Acid SCHEMBL4328805 | 0.93 | GSR (0.58) | FOLH1GSRDPP8DPP9DPP7 | |
| Hydrochloric Acid SCHEMBL10439913 | 0.93 | GSR (0.58) | FOLH1GSRDPP8DPP9DPP7 | |
| Hydrochloric Acid SCHEMBL4328812 | 0.93 | GSR (0.58) | FOLH1GSRDPP8DPP9DPP7 | |
| SCHEMBL31078174 | 0.93 | FOLH1 (0.49) | FOLH1GSRDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110798-A | Immunomodulators for bone marrow transplants | CO PHARMA CORPORATION S.R.L. (IT) | 1992-05-05 | — | — | US | disclosed |