Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 12/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 12/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 12/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9724640 | 0.99 | CHRM2 (0.56) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL10419476 | 0.82 | CHRM2 (0.72) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL10419473 | 0.82 | CHRM2 (0.72) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL661974 | 0.80 | CHRM2 (0.84) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL8872571 | 0.79 | CHRM2 (0.82) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL10420335 | 0.78 | CHRM2 (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL10420337 | 0.78 | CHRM2 (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL9704913 | 0.74 | CHRM2 (0.78) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL9704924 | 0.74 | CHRM2 (0.78) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Oxalic Acid SCHEMBL10418867 | 0.73 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | claimed |
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |