Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.67 |
| ▸ | NCOR2 | Q9Y618 | 8/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.60 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277891 | 0.90 | HDAC1 (0.73) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL675361 | 0.83 | HDAC1 (1.00) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| Tacedinaline SCHEMBL29482198 | 0.82 | HDAC1 (0.74) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| Tacedinaline SCHEMBL144794 | 0.82 | HDAC1 (0.74) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL2106529 | 0.82 | HDAC1 (0.76) | HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL672860 | 0.82 | HDAC1 (0.71) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL8401704 | 0.82 | HDAC1 (0.89) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL3763365 | 0.81 | HDAC1 (0.61) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL27406946 | 0.81 | HDAC1 (0.69) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL10373334 | 0.81 | HDAC1 (0.71) | HDAC1HDAC3HDAC2NCOR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137918-A | Anticancer agent | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | claimed |
| US-5137918-A | Anticancer agent | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |