Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724682 | 0.98 | CHRM2 (0.56) | CHRM2CHRM1KCNH2 | |
| SCHEMBL5921954 | 0.91 | CHRM2 (0.67) | CHRM2CHRM1 | |
| Oxalic Acid SCHEMBL9724653 | 0.91 | CHRM2 (0.49) | CHRM2CHRM1KCNH2 | |
| SCHEMBL9528809 | 0.85 | CHRM2 (0.51) | CHRM2CHRM1 | |
| Oxalic Acid SCHEMBL9213578 | 0.84 | CHRM2 (0.58) | CHRM2CHRM1 | |
| SCHEMBL24434414 | 0.83 | CHRM2 (0.50) | CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL10519400 | 0.79 | CHRM2 (0.62) | CHRM2CHRM1 | |
| Oxalic Acid SCHEMBL9404508 | 0.79 | CHRM2 (0.46) | CHRM2CHRM1 | |
| SCHEMBL661864 | 0.78 | CHRM2 (0.85) | CHRM2CHRM1 | |
| SCHEMBL10521548 | 0.78 | CHRM2 (0.60) | CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |