Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9724706 | 0.98 | CHRM2 (0.54) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9724619 | 0.80 | CHRM2 (0.59) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL24434496 | 0.76 | CHRM2 (0.56) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9724692 | 0.76 | CHRM2 (0.56) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL10519350 | 0.76 | CHRM2 (0.56) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9724711 | 0.76 | CHRM2 (0.52) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL9724736 | 0.75 | CHRM2 (0.54) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL10517115 | 0.75 | CHRM2 (0.54) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9724667 | 0.74 | CHRM2 (0.46) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL10588391 | 0.74 | HTR2A (0.38) | CHRM2CHRM3CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | claimed |
| US-5134146-A | SUBSTITUTED OXADIAZOLES AND THIADIAZOLES FOR USE IN THE TREATMENT OF GLAUCOMA | MERCK SHARP AND DOHME LTD. (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0459568-A2 | Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |