Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959396 | 0.88 | ESR1 (0.48) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL8959357 | 0.88 | ESR1 (0.48) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL8959382 | 0.88 | ESR1 (0.57) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL9725174 | 0.87 | ESR1 (0.47) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL8959340 | 0.87 | ESR1 (0.47) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL9627471 | 0.83 | ESR1 (0.54) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL9725135 | 0.83 | ESR1 (0.54) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL8959393 | 0.81 | ESR1 (0.42) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL8959380 | 0.80 | SMN1; SMN2 (0.57) | ESR1LMNASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL8959334 | 0.80 | SMN1; SMN2 (0.57) | ESR1LMNASMN1; SMN2MAPTHSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134136-A | Estrogenic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-07-28 | — | — | US | disclosed |