Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | MC4R | P32245 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413 | 1.00 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL4108375 | 1.00 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL2014600 | 0.91 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL3336 | 0.91 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL3325 | 0.87 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL4106328 | 0.85 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL4620899 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL3760527 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL4621205 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL5318542 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HTR1AMLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4226948-A | — | — | None | — | — | JP | disclosed |
| EP-2125772-B1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | RICHTER GEDEON NYRT (HU) | 2013-09-11 | — | — | EP | disclosed |
| JP-H04226948-A | CHIRAL SYNTHESIS OF 1-ARYL-3-AMINOPROPANE-1-OL | ELI LILLY & CO | 1992-08-17 | — | — | JP | disclosed |
| EP-0457559-A2 | Chiral synthesis of 1-aryl-3-aminopropan-1-ols | ELI LILLY AND COMPANY (US) | 1991-11-21 | — | — | EP | disclosed |