Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725994 | 0.94 | ACE (0.54) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL9547751 | 0.94 | ACE (0.54) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL9725879 | 0.94 | ACE (0.54) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL10530754 | 0.90 | ACE (0.51) | ACEABCB11LMNAPDE3AMEN1 | |
| Hydrochloric Acid SCHEMBL9725899 | 0.90 | ACE (0.51) | ACEABCB11LMNAPDE3A | |
| Bromide SCHEMBL9725808 | 0.90 | ACE (0.51) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL9726073 | 0.89 | ACE (0.49) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL9547830 | 0.87 | ACE (0.58) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL9726043 | 0.86 | ACE (0.41) | ACEABCB11 | |
| SCHEMBL16364870 | 0.86 | ACE (0.57) | ACEABCB11LMNAPDE3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098892-A | Angiotensin converting enzyme inhibitors as hypotensive agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| US-4822818-A | ANTIHYPERTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| US-4474692-A | L-Alanyl-N-(indan-2-yl)glycine, its esters and salts thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-10-02 | — | — | US | disclosed |
| EP-0051391-B1 | BICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-09-05 | — | — | EP | disclosed |
| EP-0051391-A1 | Bicyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1982-05-12 | — | — | EP | disclosed |