Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726582 | 0.92 | HMGCR (0.42) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL9726535 | 0.80 | HMGCR (0.46) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL9235124 | 0.80 | HMGCR (0.46) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL9726875 | 0.79 | HMGCR (0.45) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL9233023 | 0.78 | HMGCR (0.44) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL10610769 | 0.75 | HMGCR (0.40) | HMGCRALDH1A1USP2HSD17B10 | |
| SCHEMBL9235476 | 0.73 | HMGCR (0.46) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL10527444 | 0.72 | HMGCR (0.45) | HMGCRALDH1A1USP2HSD17B10RAB9A | |
| SCHEMBL10610763 | 0.71 | HMGCR (0.40) | HMGCRALDH1A1USP2HSD17B10 | |
| Bromide SCHEMBL9726632 | 0.71 | HMGCR (0.44) | HMGCRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4898949-A | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4898950-A | Preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| US-4824959-A | Intermediates for antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |