Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726771 | 1.00 | HMGCR (0.45) | HMGCRUSP2HSD17B10ALDH1A1HPGD | |
| SCHEMBL9726806 | 0.88 | HMGCR (0.43) | HMGCRUSP2HSD17B10ALDH1A1HPGD | |
| SCHEMBL9726481 | 0.84 | HMGCR (0.57) | HMGCRALDH1A1 | |
| SCHEMBL9726476 | 0.84 | HMGCR (0.57) | HMGCRALDH1A1 | |
| SCHEMBL9726839 | 0.83 | HSD17B10 (0.41) | HMGCRUSP2HSD17B10ALDH1A1HPGD | |
| SCHEMBL9726834 | 0.83 | HSD17B10 (0.41) | HMGCRUSP2HSD17B10ALDH1A1HPGD | |
| SCHEMBL9727161 | 0.82 | HMGCR (0.45) | HMGCR | |
| SCHEMBL9727162 | 0.82 | HMGCR (0.45) | HMGCR | |
| SCHEMBL9726717 | 0.80 | HMGCR (0.53) | HMGCRALDH1A1 | |
| SCHEMBL9727128 | 0.80 | HMGCR (0.53) | HMGCRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |