Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799347 | 1.00 | HMGCR (0.54) | HMGCRALDH1A1PKM | |
| SCHEMBL9726765 | 1.00 | HMGCR (0.54) | HMGCRALDH1A1PKM | |
| SCHEMBL9726761 | 1.00 | HMGCR (0.54) | HMGCRALDH1A1PKM | |
| SCHEMBL9799350 | 1.00 | HMGCR (0.54) | HMGCRALDH1A1PKM | |
| SCHEMBL9726628 | 0.88 | HMGCR (0.65) | HMGCR | |
| SCHEMBL9726616 | 0.88 | HMGCR (0.65) | HMGCR | |
| SCHEMBL9726623 | 0.88 | HMGCR (0.65) | HMGCR | |
| SCHEMBL9726522 | 0.88 | HMGCR (0.49) | HMGCR | |
| SCHEMBL9726530 | 0.88 | HMGCR (0.49) | HMGCR | |
| SCHEMBL9726525 | 0.88 | HMGCR (0.49) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4939265-A | Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4898949-A | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |