Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | USP14 | P54578 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491666 | 0.89 | CYP19A1 (0.49) | CYP19A1PIK3CDPIK3CA | |
| SCHEMBL21235216 | 0.81 | AOC3 (0.58) | AOC3KCNH2 | |
| SCHEMBL540942 | 0.81 | MAPK1 (0.68) | PIK3CDPIK3CAMAPK1HTT | |
| SCHEMBL9611693 | 0.80 | MAPK1 (0.67) | AOC3KCNH2MAPK1HTT | |
| SCHEMBL16729279 | 0.77 | CYP19A1 (0.56) | CYP19A1AOC3KCNH2USP14 | |
| SCHEMBL16720755 | 0.74 | CYP19A1 (0.49) | CYP19A1PIK3CDPIK3CAUSP14MAPK1 | |
| SCHEMBL9727056 | 0.74 | MAPK1 (0.40) | CYP19A1PIK3CDPIK3CAMAPK1HTT | |
| SCHEMBL9727037 | 0.74 | CYP19A1 (0.46) | CYP19A1USP14 | |
| SCHEMBL22141877 | 0.73 | AOC3 (0.43) | CYP19A1AOC3KCNH2 | |
| SCHEMBL19142835 | 0.72 | MAPK1 (0.47) | AOC3KCNH2MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149814-A | Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds | PFIZER INC (US) | 1992-09-22 | — | — | US | disclosed |
| US-5120747-A | Antiallergens, antiinflammatory agent | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5070205-A | Chemical intermediate for anticoagulants | PFIZER INC. (US) | 1991-12-03 | — | — | US | disclosed |
| EP-0310386-B1 | 4-ARYL-5-CARBAMOYL-1,4-DIHYDROPYRIDINES | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5063237-A | Antiallergens and antiinflammatory agents | PFIZER INC. (US) | 1991-11-05 | — | — | US | disclosed |
| US-4935430-A | Platelet activating factor antagonists | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0310386-A2 | 4-Aryl-5-carbamoyl-1,4-dihydropyridines | Pfizer Limited (GB) | 1989-04-05 | — | — | EP | disclosed |