Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10706021 | 0.81 | TSHR (0.42) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL8973697 | 0.76 | MAPT (0.54) | MAPTMGLLBCL9CTNNB1NPC1 | |
| SCHEMBL6963075 | 0.75 | HSD17B10 (0.42) | MAPTALDH1A1LMNAACHEHSD17B10 | |
| SCHEMBL3281669 | 0.73 | MAPT (0.44) | MAPTMGLLBCL9CTNNB1NPC1 | |
| SCHEMBL9320304 | 0.72 | CYSLTR2 (0.40) | MAPTMGLLALDH1A1ESPL1KCNH2 | |
| SCHEMBL5694459 | 0.71 | MAPT (0.53) | MAPTMGLLNPC1RAB9AHDAC3 | |
| SCHEMBL5392051 | 0.71 | MAPT (0.47) | MAPTMGLLBCL9CTNNB1NPC1 | |
| SCHEMBL11132387 | 0.70 | MAPT (0.51) | MAPTMGLLNPC1RAB9AHDAC3 | |
| SCHEMBL6674869 | 0.70 | TDP1 (0.47) | MAPTALDH1A1HTTESPL1 | |
| SCHEMBL16954944 | 0.69 | MAPT (0.44) | MAPTMGLLBCL9CTNNB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5103006-A | Calcium channel activator; inotropic agent | E. R. SQUIBB & SONS, INC. (US) | 1992-04-07 | — | — | US | disclosed |