Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 6/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972110 | 0.93 | TEK (0.44) | TEKPDE10AKDRAURKAAURKB | |
| SCHEMBL974853 | 0.91 | TEK (0.52) | TEKPDE10AKDRAURKAAURKB | |
| SCHEMBL973570 | 0.88 | TEK (0.44) | TEKPDE10AKDRAURKAAURKB | |
| SCHEMBL973511 | 0.86 | TEK (0.44) | TEKPDE10AKDRAURKAAURKB | |
| SCHEMBL973159 | 0.77 | TEK (0.71) | TEKKDRAURKAAURKBLCK | |
| SCHEMBL5262512 | 0.73 | KDR (0.58) | TEKPDE10AKDRAURKAAURKB | |
| SCHEMBL972423 | 0.71 | TEK (0.48) | TEKPDE10AKDRAURKAAURKB | |
| SCHEMBL1265159 | 0.71 | KDR (0.72) | TEKKDRAURKAAURKBLCK | |
| SCHEMBL1266363 | 0.70 | TEK (0.67) | TEKKDRAURKAAURKBLCK | |
| SCHEMBL1266076 | 0.70 | KDR (0.49) | TEKPDE10AKDRAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | disclosed |