Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.70 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.70 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9777783 | 0.89 | AKR1B1 (0.71) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9728664 | 0.89 | AKR1B1 (0.69) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL8328329 | 0.87 | AKR1B1 (0.71) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL8319320 | 0.85 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL29727574 | 0.82 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL30602643 | 0.82 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL9384195 | 0.82 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL9388567 | 0.82 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL49649 | 0.82 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9853853 | 0.80 | AKR1B1 (0.71) | AKR1B1AKR1B10AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081241-A | Diabetes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-14 | — | — | US | claimed |
| US-5081241-A | Diabetes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-14 | — | — | US | disclosed |