Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544961 | 0.98 | KCNH2 (0.46) | KCNH2NOS2FBP1ALDH1A1TLR7 | |
| SCHEMBL5545704 | 0.79 | KCNH2 (0.50) | KCNH2NOS2ALDH1A1HPGD | |
| SCHEMBL5545700 | 0.78 | KCNH2 (0.48) | KCNH2ALDH1A1HPGD | |
| SCHEMBL5537310 | 0.77 | KCNH2 (0.47) | KCNH2NOS2 | |
| SCHEMBL2867677 | 0.77 | KCNH2 (0.47) | KCNH2NOS2ALDH1A1MEN1RAB9A | |
| SCHEMBL5537302 | 0.76 | KCNH2 (0.46) | KCNH2NOS2MEN1KMT2A | |
| SCHEMBL27629471 | 0.76 | KCNH2 (0.46) | KCNH2NOS2 | |
| SCHEMBL3721914 | 0.76 | KCNH2 (0.46) | KCNH2NOS2MEN1KMT2A | |
| SCHEMBL5545607 | 0.75 | KCNH2 (0.46) | KCNH2ALDH1A1HPGD | |
| SCHEMBL2731415 | 0.74 | KCNH2 (0.44) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162360-A | Treating hypercholesterolemia and atherosclerosis; ACAT acyl-coenzyme A:-cholesterol acyltransferase | WARNER-LAMBERT COMPANY (US) | 1992-11-10 | — | — | US | disclosed |