Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11129414 | 1.00 | HTT (0.37) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15894829 | 1.00 | HTT (0.37) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11068690 | 1.00 | HTT (0.37) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15894832 | 0.86 | HTT (0.39) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9729324 | 0.85 | DRD3 (0.33) | SMN1; SMN2POLBMAPT | |
| SCHEMBL15894833 | 0.80 | MEN1 (0.37) | ALDH1A1SMN1; SMN2MEN1KMT2AALOX15 | |
| SCHEMBL11078998 | 0.79 | MAPT (0.41) | ALDH1A1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL15894838 | 0.76 | CYP3A4 (0.46) | ALDH1A1MEN1KMT2AGAAHSD17B10 | |
| SCHEMBL9728745 | 0.76 | BRD4 (0.36) | — | |
| SCHEMBL9728744 | 0.76 | BRD4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134143-A | Dopamine Agonists | ELI LILLY AND COMPANY (US) | 1992-07-28 | — | — | US | disclosed |
| US-4977160-A | DOPAMINE AGONISTS; PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4826986-A | DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1989-05-02 | — | — | US | disclosed |