Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 14/20 | 0.44 |
| ▸ | GSK3B | P49841 | 9/20 | 0.44 |
| ▸ | JAK3 | P52333 | 11/20 | 0.40 |
| ▸ | PRKACA | P17612 | 10/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.40 |
| ▸ | CLK2 | P49760 | 9/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 9/20 | 0.40 |
| ▸ | PRKX | P51817 | 9/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 9/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 9/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 9/20 | 0.40 |
| ▸ | CDK2 | P24941 | 8/20 | 0.40 |
| ▸ | CDK9 | P50750 | 8/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 8/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 8/20 | 0.40 |
| ▸ | PAK4 | O96013 | 8/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 8/20 | 0.40 |
| ▸ | STK3 | Q13188 | 8/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972965 | 1.00 | CDC7 (0.44) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL1045145 | 0.88 | CDC7 (0.61) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL1045147 | 0.88 | CDC7 (0.61) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL934901 | 0.87 | CDC7 (0.52) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL934902 | 0.87 | CDC7 (0.52) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL1046693 | 0.84 | CDC7 (0.43) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL1046694 | 0.84 | CDC7 (0.43) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL935147 | 0.82 | CDC7 (0.47) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL935149 | 0.82 | CDC7 (0.47) | CDC7GSK3BJAK3PRKACADYRK1A | |
| SCHEMBL935124 | 0.82 | CDC7 (0.52) | CDC7GSK3BJAK3PRKACADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454262-B1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LAB (US) | 2014-05-14 | — | — | EP | claimed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | claimed |
| EP-2454262-B1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LAB (US) | 2014-05-14 | — | — | EP | disclosed |
| US-8383624-B2 | Pyrrolopyrazine inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | CDC7, CDK7, CDK17 | CDC7 1/4885GSK3B 307/4885JAK3 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.