Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9731213 | 0.90 | HMGCR (0.42) | HMGCR | |
| SCHEMBL9730322 | 0.87 | HMGCR (0.50) | HMGCR | |
| SCHEMBL9730728 | 0.86 | HMGCR (0.45) | HMGCR | |
| SCHEMBL9730867 | 0.79 | HMGCR (0.40) | HMGCR | |
| SCHEMBL9729971 | 0.76 | HMGCR (0.42) | HMGCR | |
| SCHEMBL9730326 | 0.76 | HMGCR (0.51) | HMGCR | |
| SCHEMBL9730319 | 0.76 | HMGCR (0.51) | HMGCR | |
| SCHEMBL9729993 | 0.76 | HMGCR (0.54) | HMGCR | |
| SCHEMBL9730011 | 0.74 | HMGCR (0.56) | HMGCR | |
| SCHEMBL3809636 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081136-A | 1,2,3-TRIAZOLE COMPOUNDS ACTIVE AS INHIBITORS OF THE ENZYME HMG-COA REDUCTASE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON GROUP S.P.A. (IT) | 1992-01-14 | — | — | US | disclosed |
| EP-0433842-A2 | 1,2,3-Triazole derivatives active as inhibitors of the enzyme HMG-COA reductase and pharmaceutical compositions containing them | ZAMBON GROUP S.p.A. (IT) | 1991-06-26 | — | — | EP | disclosed |