Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 15/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9730010 | 0.90 | HMGCR (0.45) | HMGCRMMP2MMP9MMP12MMP13 | |
| SCHEMBL9730011 | 0.90 | HMGCR (0.56) | HMGCR | |
| SCHEMBL9729999 | 0.86 | HMGCR (0.47) | HMGCRMMP2MMP9MMP12MMP13 | |
| SCHEMBL9729993 | 0.76 | HMGCR (0.54) | HMGCR | |
| SCHEMBL9729978 | 0.76 | HMGCR (0.52) | HMGCRHDAC8 | |
| SCHEMBL9729969 | 0.76 | HMGCR (0.52) | HMGCRHDAC8 | |
| SCHEMBL9731213 | 0.72 | HMGCR (0.42) | HMGCRMMP2MMP9MMP12MMP13 | |
| SCHEMBL5761377 | 0.72 | HMGCR (0.66) | HMGCR | |
| SCHEMBL5741291 | 0.71 | HMGCR (0.58) | HMGCR | |
| SCHEMBL5741294 | 0.71 | HMGCR (0.75) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081136-A | 1,2,3-TRIAZOLE COMPOUNDS ACTIVE AS INHIBITORS OF THE ENZYME HMG-COA REDUCTASE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON GROUP S.P.A. (IT) | 1992-01-14 | — | — | US | disclosed |
| EP-0433842-A2 | 1,2,3-Triazole derivatives active as inhibitors of the enzyme HMG-COA reductase and pharmaceutical compositions containing them | ZAMBON GROUP S.p.A. (IT) | 1991-06-26 | — | — | EP | disclosed |