Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.60 |
| ▸ | HTR3A | P46098 | 4/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.60 |
| ▸ | HTR3B | O95264 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10342300 | 0.89 | CHRNA7 (0.74) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| SCHEMBL10436323 | 0.89 | CHRNA7 (0.74) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| Hydrochloric Acid SCHEMBL7291446 | 0.88 | CHRNA7 (0.72) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| Hydrochloric Acid SCHEMBL9601320 | 0.88 | CHRNA7 (0.72) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| Hydrochloric Acid SCHEMBL7278547 | 0.88 | CHRNA7 (0.72) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| SCHEMBL9369811 | 0.82 | CHRNA7 (0.66) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| SCHEMBL9369952 | 0.82 | CHRNA7 (0.66) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| SCHEMBL9369817 | 0.82 | CHRNA7 (0.66) | CHRNA7HTR3AHTR3EHTR3BALOX15 | |
| SCHEMBL9732021 | 0.78 | CHRNA7 (0.59) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7278577 | 0.76 | CHRNA7 (0.71) | CHRNA7HTR3AHTR3EHTR3BALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0323077-B1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-09-11 | — | — | EP | claimed |
| US-4983600-A | Antiemetics, antianxiety agents, gastrointestinal disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-08 | — | — | US | claimed |
| EP-0323077-A1 | Heterocyclic compounds | JOHN WYETH & BROTHER LIMITED (GB) | 1989-07-05 | — | — | EP | claimed |
| US-5106843-A | Treatment of migraine, emesis, anxiety, gastrointestinal disorders, psychological disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0323077-B1 | HETEROCYCLIC COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-4983600-A | Antiemetics, antianxiety agents, gastrointestinal disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-08 | — | — | US | disclosed |