Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.56 |
| ▸ | PPARD | Q03181 | 3/20 | 0.56 |
| ▸ | PPARA | Q07869 | 3/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 13/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733301 | 0.91 | PPARG (0.62) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10922007 | 0.86 | PPARG (0.54) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9733724 | 0.83 | CYSLTR2 (0.58) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10697713 | 0.82 | CYSLTR2 (0.64) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10554170 | 0.82 | PPARG (0.61) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9734011 | 0.81 | PPARG (0.61) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10918614 | 0.81 | PPARG (0.76) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9733378 | 0.80 | CYSLTR2 (0.62) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10919270 | 0.79 | CYSLTR2 (0.69) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9734503 | 0.79 | PPARG (0.57) | PPARGPPARDPPARACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0104885-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-06-04 | — | — | EP | claimed |
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |