Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.67 |
| ▸ | PDE1A | P54750 | 3/20 | 0.57 |
| ▸ | PDE2A | O00408 | 2/20 | 0.57 |
| ▸ | PDE9A | O76083 | 2/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE6C | P51160 | 2/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PDE6A | P16499 | 2/20 | 0.55 |
| ▸ | PDE6D | O43924 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | PDE6G | P18545 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973727 | 0.91 | PDE5A (0.67) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12823758 | 0.89 | PDE5A (0.52) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12823601 | 0.88 | PDE5A (0.71) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12824059 | 0.87 | PDE5A (0.72) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12823796 | 0.87 | PDE5A (0.62) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12823133 | 0.87 | PDE5A (0.68) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12823120 | 0.87 | PDE5A (0.64) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12922547 | 0.86 | PDE5A (0.61) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL12824055 | 0.86 | PDE5A (0.73) | PDE5APDE1APDE2APDE9APDE4A | |
| SCHEMBL974073 | 0.86 | PDE5A (0.67) | PDE5APDE1APDE2APDE9APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9155691-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2015-10-13 | — | — | US | claimed |
| US-20140179701-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2014-06-26 | — | — | US | claimed |
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | claimed |
| US-20130030174-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-01-31 | — | — | US | claimed |
| US-9155691-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2015-10-13 | — | — | US | disclosed |
| US-20140179701-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2014-06-26 | — | — | US | disclosed |
| US-8716298-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2014-05-06 | — | — | US | disclosed |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2013-03-07 | — | — | US | disclosed |
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | disclosed |
| US-20130030174-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-01-31 | — | — | US | disclosed |
| US-20040152700-A1 | Novel use of 2-phenyl-substituted imidazotriazinones | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-08-05 | — | — | US | disclosed |
| US-20040067945-A1 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2004-04-08 | — | — | US | disclosed |
| EP-1392314-A1 | NOVEL USE OF 2-PHENYL-SUBSTITUTED IMIDAZOTRIAZINONES | Bayer HealthCare AG (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6566360-B1 | Administering 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position for therapy of hypertrophy of the prostate, incontinence or female sexual dysfunction in mammals | BAYER AKTIENGESELLSCHAFT (DE) | 2003-05-20 | — | — | US | disclosed |
| WO-2003011262-A2 | USE OF 2-ALKOXYPHENYL-SUBSTITUTED IMIDAZOTRIAZINONES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CGMP REGULATED PROCESSES | BAYER HEALTHCARE AG (DE) | 2003-02-13 | — | — | WO | disclosed |
| WO-2002089808-A1 | NOVEL USE OF 2-PHENYL-SUBSTITUTED IMIDAZOTRIAZINONES | BAYER HEALTHCARE AG (DE) | 2002-11-14 | — | — | WO | disclosed |
| US-6362178-B1 | TREATMENT OF CARDIOVASCULAR DIORDERS, CEREBROVASCULAR DISORDERS, UROGENITAL DISORDERS AND ERECTILE DYSFUNCTION | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-26 | — | — | US | disclosed |
| EP-1174431-A2 | 2-Phenyl-substituited Imidazotriazinones as Phoshodiesterase Inhibitors | Bayer Aktiengesellschaft (DE) | 2002-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059844-A1 | 2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS | PDE3B, PDE3A, PDE2A | PDE5A 4/4885PDE1A 25/4885PDE2A 3/4885 |
| US-20040067945-A1 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors | PDE3B, PDE3A, PDE2A | PDE5A 4/4885PDE1A 25/4885PDE2A 3/4885 |
| US-20040152700-A1 | Novel use of 2-phenyl-substituted imidazotriazinones | PDE7A, PDE4A, PDE5A | PDE5A 3/4885PDE1A 4/4885PDE2A 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.