Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734864 | 1.00 | CYP2C19 (0.31) | CYP2C19PDCD1CD274 | |
| SCHEMBL15392534 | 0.94 | — | — | |
| SCHEMBL9734009 | 0.94 | — | — | |
| SCHEMBL9734007 | 0.94 | — | — | |
| SCHEMBL9735303 | 0.79 | MEN1 (0.32) | CD274 | |
| SCHEMBL9735306 | 0.79 | MEN1 (0.32) | CD274 | |
| SCHEMBL11500645 | 0.79 | MEN1 (0.32) | CD274 | |
| SCHEMBL27088771 | 0.77 | — | — | |
| SCHEMBL3599364 | 0.77 | EPHX2 (0.31) | — | |
| SCHEMBL21225230 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166136-A | SPIROLACTAM CONTAINING PEPTIDES | GLAXO GROUP LIMITED (GB) | 1992-11-24 | — | — | US | disclosed |
| EP-0360390-A1 | Spirolactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-03-28 | — | — | EP | disclosed |