SCHEMBL9735763

SCHEMBL9735763

C[C@H](OS(C)(=O)=O)[C@H](C)[C@](O)(Cn1cncn1)c1ccccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.40
KMT2A Q03164 3/20 0.38
CYP3A4 P08684 10/20 0.37
CYP2C9 P11712 9/20 0.37
CYP2C19 P33261 9/20 0.37
CYP1A2 P05177 6/20 0.37
CYP2D6 P10635 6/20 0.37
KCNH2 Q12809 2/20 0.37
LMNA P02545 2/20 0.37
CYP2B6 P20813 1/20 0.37
CYP3A5 P20815 1/20 0.37
CYP3A7 P24462 1/20 0.37
MAPK1 P28482 1/20 0.37
CYP3A43 Q9HB55 1/20 0.37
CYP46A1 Q9Y6A2 1/20 0.37
ALDH1A1 P00352 1/20 0.36
MEN1 O00255 1/20 0.35
FDPS P14324 1/20 0.34
CYP19A1 P11511 1/20 0.34
CYP11B1 P15538 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9735760 1.00 HSP90AA1 (0.40) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9736623 1.00 HSP90AA1 (0.40) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9736343 0.86 CYP3A4 (0.48) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9737224 0.86 CYP3A4 (0.48) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9736505 0.86 CYP3A4 (0.48) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9736337 0.86 CYP3A4 (0.48) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9736466 0.84 KMT2A (0.48) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9736461 0.84 KMT2A (0.48) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9737059 0.82 CYP3A4 (0.54) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL9735748 0.82 CYP3A4 (0.54) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5134152-A 1,2,4-Triazole compounds SANKYO COMPANY, LIMITED (JP) 1992-07-28 US disclosed
EP-0431968-A1 Oxetane derivatives, their preparation and their use as anti-fungal or fungicidal agents Sankyo Company Limited (JP) 1991-06-12 EP disclosed