Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL9735924 | 1.00 | KDM4E (0.42) | KDM4ECYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL9197163 | 0.92 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL9735697 | 0.92 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL9197539 | 0.92 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL9844129 | 0.92 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL9821120 | 0.92 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL9200913 | 0.92 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL9201689 | 0.92 | CYP3A4 (0.42) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL2346412 | 0.82 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 | |
| SCHEMBL8574154 | 0.82 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134152-A | 1,2,4-Triazole compounds | SANKYO COMPANY, LIMITED (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0431968-A1 | Oxetane derivatives, their preparation and their use as anti-fungal or fungicidal agents | Sankyo Company Limited (JP) | 1991-06-12 | — | — | EP | disclosed |