Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | BHMT | Q93088 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12258200 | 0.89 | TDP1 (0.53) | TDP1FFAR3SMN1; SMN2ALDH1A1 | |
| SCHEMBL258152 | 0.84 | SLC22A6 (0.50) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| SCHEMBL6738239 | 0.81 | SLC22A6 (0.47) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| SCHEMBL14109598 | 0.81 | SLC22A6 (0.47) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| Ammonia Solution, Strong SCHEMBL28582304 | 0.81 | TDP1 (0.53) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| SCHEMBL10902055 | 0.81 | SLC22A6 (0.47) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| SCHEMBL11112412 | 0.81 | SLC22A6 (0.47) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| Ethane SCHEMBL5968227 | 0.81 | SLC22A6 (0.47) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| SCHEMBL11112780 | 0.81 | SLC22A6 (0.47) | TDP1FFAR3SMN1; SMN2SLC22A6BHMT | |
| SCHEMBL12258211 | 0.80 | CYP2C19 (0.45) | TDP1FFAR3SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458193-B1 | Proline compounds as Granzyme B inhibitors | VIDA THERAPEUTICS INC. (CA) | 2016-10-04 | — | — | US | disclosed |
| WO-2016015159-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS, INC. (CA) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016015160-A1 | CYCLIC UREA COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS, INC. (CA) | 2016-02-04 | — | — | WO | disclosed |
| US-5081145-A | Contractile prostaglandin antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |
| EP-0166591-B1 | INDOLE-2-ALKANOIC ACIDS AND THEIR USE AS PROSTAGLANDIN ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1989-11-23 | — | — | EP | disclosed |
| EP-0166591-A2 | Indole-2-alkanoic acids and their use as prostaglandin antagonists | MERCK FROSST CANADA INC. (CA) | 1986-01-02 | — | — | EP | disclosed |