SCHEMBL9736259

SCHEMBL9736259

COc1ccc2c(c1)c(C)c(CCC(=O)O)n2Cc1ccc(Cl)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 6/20 0.69
AKR1C2 P52895 6/20 0.69
AKR1C4 P17516 3/20 0.69
AKR1C1 Q04828 3/20 0.69
PTGS1 P23219 2/20 0.69
AR P10275 2/20 0.69
CYP1A2 P05177 3/20 0.64
CYP3A4 P08684 3/20 0.64
CYP2C9 P11712 3/20 0.64
TSHR P16473 3/20 0.64
CYP2C19 P33261 3/20 0.64
LMNA P02545 2/20 0.64
MAPT P10636 2/20 0.64
PMP22 Q01453 2/20 0.64
HIF1A Q16665 2/20 0.64
MEN1 O00255 1/20 0.64
RGS12 O14924 1/20 0.64
ALDH1A1 P00352 1/20 0.64
PKM P14618 1/20 0.64
NFKB1 P19838 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9736403 0.94 CYP1A2 (0.61) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9735576 0.93 CYP1A2 (0.60) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9741370 0.91 AKR1C3 (0.60) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9736960 0.90 CYP1A2 (0.57) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9737792 0.90 AR (0.57) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9738094 0.89 AKR1C3 (0.56) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9741283 0.89 PTGES2 (0.57) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9738239 0.89 AR (0.55) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9737790 0.88 AR (0.54) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1
SCHEMBL9736206 0.87 AR (0.53) AKR1C3AKR1C2AKR1C4AKR1C1PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5081145-A Contractile prostaglandin antagonists MERCK FROSST CANADA, INC. (CA) 1992-01-14 US disclosed
EP-0166591-B1 INDOLE-2-ALKANOIC ACIDS AND THEIR USE AS PROSTAGLANDIN ANTAGONISTS MERCK FROSST CANADA INC. (CA) 1989-11-23 EP disclosed
EP-0166591-A2 Indole-2-alkanoic acids and their use as prostaglandin antagonists MERCK FROSST CANADA INC. (CA) 1986-01-02 EP disclosed