SCHEMBL9736893

SCHEMBL9736893

CC[C@@H](C)[C@](O)(Cn1cncn1)c1ccc(Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.56
CYP3A4 P08684 7/20 0.51
ALDH1A1 P00352 1/20 0.51
HSP90AA1 P07900 2/20 0.45
CYP2C9 P11712 6/20 0.42
CYP2C19 P33261 6/20 0.42
CYP1A2 P05177 3/20 0.42
CYP2D6 P10635 3/20 0.42
KCNH2 Q12809 2/20 0.42
HTT P42858 2/20 0.40
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
LMNA P02545 2/20 0.40
CYP2B6 P20813 1/20 0.40
CYP3A5 P20815 1/20 0.40
CYP3A7 P24462 1/20 0.40
MAPK1 P28482 1/20 0.40
CYP3A43 Q9HB55 1/20 0.40
CYP46A1 Q9Y6A2 1/20 0.40
PDCD1 Q15116 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9736887 1.00 KMT2A (0.56) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL9194942 0.90 KMT2A (0.56) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL14404565 0.88 KMT2A (0.54) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL10599398 0.87 KMT2A (0.59) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL9004966 0.87 KMT2A (0.59) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL9004930 0.87 KMT2A (0.59) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL10599395 0.87 KMT2A (0.59) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL9521603 0.86 KMT2A (0.57) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL9012732 0.86 KMT2A (0.57) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9
SCHEMBL8808838 0.86 KMT2A (0.57) KMT2ACYP3A4ALDH1A1HSP90AA1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5134152-A 1,2,4-Triazole compounds SANKYO COMPANY, LIMITED (JP) 1992-07-28 US disclosed
EP-0431968-A1 Oxetane derivatives, their preparation and their use as anti-fungal or fungicidal agents Sankyo Company Limited (JP) 1991-06-12 EP disclosed