SCHEMBL9737632

SCHEMBL9737632

CC(C)[C@@H]1c2ccc(F)cc2CC[C@@]1(O)CCNCCCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.52
CYP2D6 P10635 6/20 0.40
DRD3 P35462 2/20 0.40
SLC6A3 Q01959 2/20 0.40
DRD2 P14416 1/20 0.40
DRD4 P21917 1/20 0.40
CACNA1H O95180 4/20 0.39
CACNA1C Q13936 2/20 0.39
MAPT P10636 4/20 0.38
CACNA1B Q00975 3/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ALDH1A1 P00352 2/20 0.38
KCNH2 Q12809 3/20 0.37
ABCB11 O95342 2/20 0.37
NPC1 O15118 1/20 0.37
CACNA1G O43497 1/20 0.37
CACNA1F O60840 1/20 0.37
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10797045 0.99 CYP3A4 (0.51) CYP3A4CYP2D6DRD3SLC6A3DRD2
Hydrochloric Acid SCHEMBL10798620 0.93 CYP3A4 (0.49) CYP3A4CYP2D6DRD3SLC6A3CACNA1H
SCHEMBL9737984 0.89 CYP3A4 (0.46) CYP3A4CYP2D6ALDH1A1CYP1A2CYP2C9
Hydrochloric Acid SCHEMBL10793227 0.88 CYP3A4 (0.45) CYP3A4CYP2D6MAPTMEN1KMT2A
SCHEMBL9827453 0.86 CYP3A4 (0.45) CYP3A4CYP2D6MEN1KMT2AALDH1A1
SCHEMBL9736711 0.86 CYP3A4 (0.45) CYP3A4CYP2D6MEN1KMT2AALDH1A1
Hydrochloric Acid SCHEMBL10798394 0.86 CYP3A4 (0.43) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
Hydrochloric Acid SCHEMBL10791965 0.86 CYP3A4 (0.45) CYP3A4CYP2D6DRD3SLC6A3CACNA1H
Hydrochloric Acid SCHEMBL9736378 0.86 CYP3A4 (0.45) CYP3A4CYP2D6MAPTMEN1KMT2A
Hydrochloric Acid SCHEMBL9829237 0.86 CYP3A4 (0.45) CYP3A4CYP2D6MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5120759-A TETRAHYDRONAPHTHALENE DERIVATIVES FOR IMPROVING SHORT-TERM MEMORY HOFFMANN-LA ROCHE INC. (US) 1992-06-09 US disclosed
EP-0388739-A1 Tetrahydronaphthalene derivates F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1990-09-26 EP disclosed