Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 16/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417796 | 0.81 | PDE5A (0.75) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL13348916 | 0.80 | MRGPRX4 (0.71) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL10740242 | 0.78 | CYSLTR1 (0.73) | MRGPRX4SMN1; SMN2PDE5A | |
| SCHEMBL481005 | 0.75 | CYSLTR1 (0.68) | MRGPRX4PDE5A | |
| SCHEMBL22480530 | 0.74 | MRGPRX4 (1.00) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL481630 | 0.74 | MAPT (0.68) | MRGPRX4SMN1; SMN2 | |
| SCHEMBL481099 | 0.73 | MRGPRX4 (0.61) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL9417930 | 0.72 | MRGPRX4 (0.61) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL18428642 | 0.72 | MAPT (0.70) | MRGPRX4SMN1; SMN2 | |
| SCHEMBL481006 | 0.72 | CYSLTR1 (0.65) | SMN1; SMN2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |