Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 16/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | HPGD | P15428 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | PTGES | O14684 | 7/20 | 0.61 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252820 | 0.90 | PTGES2 (1.00) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL29503039 | 0.90 | PTGES2 (1.00) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL9736032 | 0.86 | PTGES2 (0.61) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL9736499 | 0.85 | PTGES2 (0.71) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL9452885 | 0.83 | PTGES2 (0.58) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL9736106 | 0.83 | PTGES2 (0.69) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL10508813 | 0.82 | PTGES2 (0.73) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL9738717 | 0.81 | PTGES2 (0.79) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL9738077 | 0.81 | PTGES2 (0.83) | PTGES2KDM4ECYP1A2CYP3A4MAPT | |
| SCHEMBL9669124 | 0.80 | PTGES2 (0.77) | PTGES2KDM4ECYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166591-B1 | INDOLE-2-ALKANOIC ACIDS AND THEIR USE AS PROSTAGLANDIN ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1989-11-23 | — | — | EP | claimed |
| EP-0166591-A2 | Indole-2-alkanoic acids and their use as prostaglandin antagonists | MERCK FROSST CANADA INC. (CA) | 1986-01-02 | — | — | EP | claimed |
| US-5081145-A | Contractile prostaglandin antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |
| EP-0166591-B1 | INDOLE-2-ALKANOIC ACIDS AND THEIR USE AS PROSTAGLANDIN ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1989-11-23 | — | — | EP | disclosed |
| EP-0166591-A2 | Indole-2-alkanoic acids and their use as prostaglandin antagonists | MERCK FROSST CANADA INC. (CA) | 1986-01-02 | — | — | EP | disclosed |