⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13185492 | 1.00 | — | — | |
| SCHEMBL12567851 | 1.00 | — | — | |
| SCHEMBL17433530 | 0.83 | BRD4 (0.37) | — | |
| SCHEMBL8310993 | 0.79 | KMT2A (0.33) | — | |
| SCHEMBL17433539 | 0.79 | BRD4 (0.41) | — | |
| SCHEMBL8298089 | 0.73 | KMT2A (0.32) | — | |
| SCHEMBL8298058 | 0.73 | KMT2A (0.32) | — | |
| SCHEMBL262126 | 0.72 | — | — | |
| SCHEMBL9123388 | 0.72 | — | — | |
| SCHEMBL22715993 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3985001-A1 | PHARMACEUTICAL COMPOSITION USEFUL IN INHIBITING IDH1 | Les Laboratoires Servier SAS (FR) | 2022-04-20 | — | — | EP | disclosed |
| EP-2804851-B1 | LACTAM DERIVATES USEFUL AS INHIBITORS OF MUTANT IDH1 | AGIOS PHARMACEUTICALS INC (US) | 2018-07-18 | — | — | EP | disclosed |
| US-20170015703-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | SERVIER PHARMACEUTICALS LLC | 2017-01-19 | — | — | US | disclosed |
| US-9474779-B2 | Therapeutically active compositions and their methods of use | AGIOS PHARMACEUTICALS, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20160130298-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | SERVIER PHARMACEUTICALS LLC | 2016-05-12 | — | — | US | disclosed |
| WO-2015010297-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2015-01-29 | — | — | WO | disclosed |
| US-20150031627-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC (US) | 2015-01-29 | — | — | US | disclosed |
| US-20130190249-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC (US) | 2013-07-25 | — | — | US | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| CN-1014894-B | Process for preparing 4, 4-dialkyl-2-azetidinones | SQUIBB & SONS INC (US) | 1991-11-27 | — | — | CN | disclosed |
| CN-1055736-A | 4, the preparation method of 4-dialkyl group-2-azetidinones | SQUIBB & SONS INC (US) | 1991-10-30 | — | — | CN | disclosed |
| CN-86100736-A | Process for preparing 4, 4-dialkyl-2-azetidinones | — | 1986-10-22 | — | — | CN | disclosed |
| US-4421844-A | COMPOUND WHICH SPLITS OFF ACID AND CLEAVABLE ETHER COMPOUND | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-12-20 | — | — | US | disclosed |
| EP-0043039-A2 | Process for preparing 1,7-octadiene | EC ERDÖLCHEMIE GMBH (DE) | 1982-01-06 | — | — | EP | disclosed |